Charles Holmes is a distinguished scholar and the director of the Center for Innovation in Global Health — a joint initiative of the O’Neill Institute and Georgetown University Medical Center — and serves as a professor of medicine at Georgetown University Medical School. He conducts health systems research and provides strategic support to governments, as well as multilateral and private sector organizations for improved health systems performance.

Holmes served as chief medical officer and deputy U.S. global AIDS coordinator for the PEPFAR program in the Department of State during the Obama administration. In 2013, he became CEO of the Centre for Infectious Disease Research in Zambia (CIDRZ) where he spent four years working to improve the capacity of Zambia’s healthcare system. Holmes has extensive diplomatic experience and is a life member of the Council on Foreign Relations. He is also an advisor to the Bill & Melinda Gates Foundation and the World Health Organization (WHO), where he serves as co-chair of the WHO Global Working Group for HIV Service Quality. Holmes is widely published in the research and policy literature and collaborated with former Senate majority leaders, Bill Frist and Tom Daschle, to write a 2018 report on strategic health diplomacy for the Bipartisan Policy Center in Washington, D.C.

Holmes trained in internal medicine and infectious diseases at Massachusetts General Hospital and Harvard Medical School. He has served on the faculty of Johns Hopkins School of Medicine since 2011, where he is an attending physician on the Mann infectious disease consult service at Johns Hopkins Hospital. He also serves as an adjunct faculty at the Bloomberg School of Public Health. He attended medical school at Wayne State University and received an MPH in epidemiology and international health from the University of Michigan and a B.A. from Kalamazoo College.


O'Neill Initiatives

Related Projects

Blantyre Prevention Strategy

Developing a replicable model for effective HIV prevention by defining, optimizing, and embedding core capabilities to successfully end the epidemic and strengthen health security.

Learn More

Explore our experts

O’Neill’s experts bring experience from academia, government, civil society, private practice, and nongovernmental organizations to a wide variety of topics in national and global health law.

View all of our experts

Explore our faculty

Georgetown Law’s health law courses are taught by a diverse faculty of academics, subject matter experts, and practitioners from government, international organizations, and private practice.

View all of our faculty

Explore our staff

The O’Neill Institute’s work is led by a talented team of lawyers, researchers, academics, administrators, and public policy experts.

View all of our staff